Daniel Marcellino , Diego Guidolin , Amina S . Woods and Luigi F . Agnati G - Protein - Coupled Receptors Heterodimers and Receptor Mosaics of Different Types of
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Sci./Am.Physiol. Soc.. ESSN: 1548-9221. Visit our website at http://www.the-aps.org/. American Physiological Society, 9650 Rockville Pike, Bethesda MD 20814-3991. © 2008 Int. Union Physiol. the physiological developments. It is published bimonthly in February, April, June, August, October, and December by (formerly published as News in Physiological Science) publishes brief review articles on major Physiology by gest on N ovem er 7, 2016 http://physioline.physiology.org/ D ow nladed fom
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Heterodimers and receptor mosaics of different types of G-protein-coupled receptors.
Through an assembly of interacting GPCRs, heterodimers and high-order heteromers (termed receptor mosaics) are formed and lead to changes in the agonist recognition, signaling, and trafficking of participating receptors via allosteric mechanisms, sometimes involving the appearance of cooperativity. This field has now become a major research area, and this review deals with their physiology bein...
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receptors, the ed (56). In 200 detected hete adenosine A1 the first demo with different the agonistdopamine D2 the same year The coimm tors has the dr tion using advances were cal methods b [bioluminesce and fluorescen became possi heterodimers FRET techniq mosaic could b after its demo (35, 52). Thes investigation o ous expansi approaches in combined BR complementa Interestingly, physical reso...
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G protein-coupled receptors (GPCRs) oligomerization has emerged as a vital characteristic of receptor structure. Substantial experimental evidence supports the existence of GPCR-GPCR interactions in a coordinated and cooperative manner. However, despite the current development of experimental techniques for large-scale detection of GPCR heteromers, in order to understand their connectivity it i...
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G-protein-coupled receptors (GPCRs) represent the largest family of cell surface receptors, and have evolved to detect and transmit a large palette of extracellular chemical and sensory signals into cells. Activated receptors catalyze the activation of heterotrimeric G proteins, which modulate the propagation of second messenger molecules and the activity of ion channels. Classically thought to...
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